The effect of "slimy component" fucoidan that can be expected to improve immunity

Fucoidan is a kind of sulfated polysaccharide that is contained in the transparent slimy composition that covers the surface of mozuku seaweed and kelp. This slimy ingredient prevents bacteria from entering the wound when the stem and leaves are damaged by tidal flow and sand, preventing dryness and maintains water-holding properties.
The fucoidan was discovered by Swedish scholar Kylin in 1913. In recent years, the main concern is its effect of improving immunity and anti-allergy, etc. At present, the research of fucose gum in cosmetic and nutritional supplement is also promoted all over the world.
Fucoidan has the functions of improving blood circulation system, anti-cancer, anti-metastasis and improving the immune system and other functions. It plays an effective role in the prevention of diseases related to living habits . In particular, its physiological role of prevention of life-related diseases is also clarified through research.

Mechanism of Anti-metastasis Effect of Fucoidan

Proliferation → inhibition by fucoidan (growth factor inactivation)

When cancer cells appear, they begin to proliferate slowly. The proliferation mechanism of cancer cells is through self-secreting proliferators to connect to the antenna of cell surface receptors to proliferate.

Angiogenesis → inhibition by fucoidan

For blood vessels, neovascularization inducers are further secreted. The new blood vessels then extend from the blood vessels to the cancer cells. Cancer cells absorb nutrients through new blood vessels and begin to grow and proliferate rapidly.

Implantation on vascular endothelial cells → inhibition by fucoidan

Cancer cells that finished growing and proliferating invade blood vessels and move along the blood stream into the distant places. Eventually, the cancer cells use an antenna called receptors to connect to the endothelial cells in the blood vessels and implant.

Vascular membrane destruction → inhibition by fucoidan

Cancer cells implanted in vascular endothelial cells enzymic degraded as the collagen, which acts as a vascular protective membrane, and detached from the blood vessels. Then grow and proliferates again with that as the next stronghold.

Mechanism of Anti-allergic Effect of Fucoidan

Allergy is an immune disease caused by an overreaction of the immune system.
Immune cells include macrophages that constantly patrol the body and investigate foreign bodies, T cells that are the immune cell commander, and B cells that produce antibodies.

Macrophage Investigation

If allergens such as pollen or indoor dust invade the body, macrophages will first investigate.

Secretion of command transmitting substances → inhibition by fucoidan

After investigation, if the macrophage sends a signal of "foreign body invasion", the T cell will send out a command transmitting substances and tells the B cell to "produce antibodies quickly".

Antibody production

B cells that receive the command transmitting substances will produce antibodies quickly. The antibody is emitted in the shape of a Y-shaped arrow and repeatedly punctures the mast cells.

Antibody adhesion of allergen → histamine secretion → fucoidan transplantation

Antibodies stabbed into the mast cells as antennas, and if allergens stick to them, mast cells are stimulated to secrete a toxin called histamine. Since histamines irritate nerves, symptoms such as itching of the skin, eyes, and nose, and bronchial constriction occur. This is the mechanism of allergy.

First of all, the fucoidan will organize the command transmitting substances of ②.
Then it prevents antibody of the ④ allergen from adhesion.
Because fucoidan is pre-attached to antibodies that pierces into the mast cells, the allergens cannot block and attach to antibodies, resulting in histamine not secreted.